Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer
نویسندگان
چکیده
Background: Peroxisome proliferator-activated receptors (PPARs) have a pivotal role in regulating genes that are involved in lipid
منابع مشابه
Role of peroxisome proliferator-activated receptor alpha and gamma in antiangiogenic effect of pomegranate peel extract
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Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor (PPAR ) can be prompted to undergo growth arrest and differentiation when treated with synthetic PPAR ligands. To evaluate the therapeutic potential of increased PPAR signaling in vivo, we generated transgenic mice that express a constitutively active form of PPAR in mammary gland. These mice are indist...
متن کاملThe increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usage.
Peroxisome proliferator-activated receptor-gamma1 (PPARgamma1) is transactivated by a wide range of ligands in normal human mammary epithelial and breast cancer cells. Although transactivation of PPARgamma mediates the expression of genes that are markers of differentiation, its overexpression in cancers of the breast, thyroid, colon, and lung suggests its dysregulation may play a role in oncog...
متن کاملPeroxisome Proliferator-Activated Receptor γ as a Therapeutic Target in Human Breast Cancer
Objective: Peroxisome proliferator-activated receptor γ (PPARγ) is aberrantly expressed in most breast tumors, suggesting the potential of agents that target this receptor in treatment and chemoprevention of breast cancer. However, whether PPARγ leads to the promotion or reduction of tumor formation has remained controversial and is further complicated by the ability of its available thiazolidi...
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